In recent years it has become clear that many neurons are distributed in the cortex by tangential migration occurring during fetal development. We are examining the chemotactic regulation of migration of GABAergic interneurons from their subcortical origins and Cajal-Retzius cells from their origins at the edges of the cortex to their appropriate laminar positions.
Control of Cortical Migration
Interneurons marked by GFP migrating in a cortical slice from an E16.5 embryo
Cajal-Retzius cells marked by LacZ expression in a transgenic marker mouse line