We have become very interested in the role of the pial meninges, the membranous covering of the brain, in regulating the morphogenesis and layering of cortical neurons. The lab has identified factors produced by the meninges that are crucial for regulating the position of neurons in superficial cortical layers. Future studies will expand on these findings by determining the molecular events controlled by meningeally produced factors and beginning to examine the molecular development of the meningeal cells themselves.
Cortical-Meningeal Interactions
Distribution of ECM proteins made by meningeal fibroblasts
A chemoattractant (red) made by meninges attracts superficial cortical neurons (green)