We are interested in the molecular mechanisms that regulate the differentiation of neural precursor cells into neurons and glial cells. We study these questions both in vitro using neural stem cell cultures and in vivo in the dentate gyrus. These studies focus on the roles of several morphogenic signaling molecules as well as the transcription factors that act as master regulators of these events.
Regulation of Neurogenesis
Cellular organization of the stem cell niche in the dentate gyrus.
Neuronal differentiation in cultured postanatal neural precursor cells