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Neonatal Brain Disorders Laboratory
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Donna Ferriero
Xiangning Jiang
Patrick McQuillen
Ann Sheldon
Ziniada Vexler

Patrick McQuillen MD

Associate Professor in Residence

My lab is interested in the relationship between brain development and hypoxic-ischemic brain injury. In particular, we study the role of a transient population of cortical neurons, subplate neurons, important for visual system development.  In a rodent model of preterm human periventricular white matter injury, we have determined that subplate neurons are selectively vulnerable to hypoxic-ischemic injury. We are examining the consequences of premature subplate neuron cell death on visual system development and function. In related experiments, we are employing a novel method for purifying and culturing subplate neurons to study the molecular mechanisms of subplate neuron vulnerability to hypoxia-ischemia. The central hypothesis of this work is that developmental plasticity mechanisms may represent a vulnerability or protective mechanism depending upon the timing and context of injury. Our objective is to develop age-specific neuroprotective therapies validated by neural systems-specific outcome measures.

My clinical research interests are in the identification and care of neonates and children with hypoxic ischemic brain injury. Along with Drs Steven Miller and George Gregory, we are using pre- and postoperative magnetic resonance imaging and spectroscopy and near infrared spectroscopy to determine the timing and significance of brain injury in children undergoing cardiopulmonary bypass for the correction of congenital heart disease.   We will use techniques to evaluating the efficacy of fructose-1, 6-bisphosphate administered prior to cardiopulmonary bypass to prevent brain injury in these children

contact: mcquillp@peds.ucsf.edu