Yiguo Shen, Ph.D.
||NCIRE Staff Research Associate III
||Jingzhou, Hubei Province, China
|In Lab Since:
Neuro-inflammatory response plays a critical role in the post stroke neurodegeneration process,
inhibition of such could potentially reduce neuron loss and help brain function recovery. Microglia
is the major player in neuro-inflammation. My research focuses on the molecular mechanism controlling
microglia activation upon pathogen stimulation or brain ischemia conditions, in a in vitro cell culture
model and in vivo mouse model. I am paticularly interested in regulating microglia activation through
Yiguo Shen, Wooping Ge, Yulong Li, Pascal Kaeser, Hsien-Yang Lee, Richard Tsien, Thomas C. Sudhof, Lily Jan, Ying-Hui Fu, Louis J. Ptacek. A novel synaptic protein mutated in paroxysmal dyskinesia inhibits RIM-dependent neurotransmitter release. (Manuscript in Preparation).
Hsien-yang Lee, Junko Nakayama, Ying Xu, Xueliang Fan, Maha Karouani, Yiguo Shen , Emmanuel N. Pothos, Ellen J. Hess, Ying-Hui Fu , Robert H. Edwards and Louis J. Ptácek. A mouse model of paroxysmal non-kinesigenic dyskinesia shows altered dopaminergic signaling. 2011. (Revision).
Yiguo Shen, Hsien-Yang Lee, Joel Rawson, Sunil Ojha, Patricia Babbitt, Ying-Hui Fu and Louis J. Ptácek. Mutations in PNKD Causing Paroxysmal Dyskinesia Alters Protein Cleavage and Stability. Human Molecular Genetics. 2011, 20:2322-2332.
Yiguo Shen, Andrew S. Peterson. Atrophins, emerging roles in development and neurodegenerative disease. Cellular and Molecular Life Sciences. 2009, 66:437 – 446.
Yiguo Shen, Gena Lee, Youngshik Choe, J. Susie Zoltewicz, Andrew S. Peterson. Functional architecture of atrophins. Journal of Biological Chemistry. 2007, 282: 5037-5044.
Scott R. May, Amir M. Ashique, Mattias Karlen, Baolin Wang, Yiguo Shen, Konstantinos Zarbalis, Jeremy Reiter, Johan Ericson, Andrew S. Peterson. Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Developmental Biology. 2005, 287:378-389.
Wanke Zhang, Yiguo Shen, Xinjian He, Baoxin Du, Zongming Xie, Guangzuo Luo, Jinsong Zhang, Shouyi Chen. Characterization of a novel cell cycle-related gene from Arabidopsis. Journal of Experimental Botany. 2005, 56: 807 - 816.
Konstantinos Zarbalis, Scott R. May, Yiguo Shen, Marc Ekker, John L. R. Rubenstein, Andrew S. Peterson. A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development. PLoS Biology 2004, 2:1177-1187.
Yiguo Shen, Wanke Zhang, Dongqing Yan, Baoxin Du, Jinsong Zhang, Qiang Liu, Shouyi Chen. Characterization of a DRE-binding transcription factor from a halophyte Atriplex hortensis. Theoretical and Applied Genetics. 2003, 107:155–161.
Yiguo Shen, Wanke Zhang, Sijie He, Jinsong Zhang, Qiang Liu, Shouyi Chen. An EREBP/AP2-type protein in Triticum aestivumwas was a DRE-binding transcription factor induced by cold, dehydration and ABA stress. Theoretical and Applied Genetics. 2003, 106:923.930.
Yiguo Shen, Baoxin Du, Wanke Zhang, Jinsong Zhang, Shouyi Chen. AhCMO, regulated by stresses in Atriplex hortensis, can improve drought tolerance in transgenic tobacco. Theoretical and Applied Genetics. 2002, 105:815–821.
Yiguo Shen, Dongqin Yan, Wanke Zhang, Baoxin Du, Jinsong Zhang, Qiang Liu, Shouyi Chen. Novel halophyte EREBP/AP2-type DNA binding protein improves salt tolerance in transgenic tobacco. ACTA BOTANICA SINICA. 2003, 45: 82-87.
Yiguo Shen, Wanke Zhang, Dongqin Yan, Baoxin Du, Jinsong Zhang, Shouyi Chen. Overexpression of proline transporter gene isolated from halophyte confers salt tolerance in Arabidopsis. ACTA BOTANICA SINICA. 2002, 44: 956-962.
Yiguo Shen, Shouyi Chen. Review: Molecular mechanism of plant responses to salt stress. Hereditas(Beijing) 2001, 23: 365-369.
Yiguo Shen, Baoxin Du, Jinsong Zhang, Shouyi Chen. Cloning and characterization of CMO gene from Atriplex hortensis. Chinese Journal of Biotechnology. 2001, 17:1-6.
Jinsong Zhang, Can Xie, Yiguo Shen, Shouyi Chen. A two-component gene (NTHK1) encoding a putative ethylene receptor homolog is both developmentally- and wounding -regulated in tobacco. Theoretical and Applied Genetics. 2001, 102: 815-824.
Xiuyu Dai, Yiguo Shen, Jian Zhou. Study on the trehalose stress protection on Streptococcus thermophilus and Lactobacillus plantarum. Microbiology(Beijing) 2001, 28: 46-50.
Wei Dong, Qingkai Yang, Yiguo Shen, Shouyi Chen. RAPD markers tightly linked to the locus resistant to race 1 of Cercospora sojina in soybean. High Technology Letters.1999, 10: 49-51.