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Seok Joon Won, Ph.D.

| Position: |
Research Scientist |
| Degree(s): |
Ph.D. (2001) |
| Born: |
Seoul, S. Korea |
| In Lab Since: |
2007 |
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Bio Pending
Research Interests
Pending
Selected Publications
- SJ Won and
S Sohn (1995) Induction of metallothionein-like protein in the rat brain
by intracerebroventricular cadmium treatment. Korean J Zool 38: 238-247
- BJ Gwag, EY Kim,
BR Ryu, SJ Won, HW Ko, YJ Oh, YG Cho, SJ Ha and YC Sung (1998)
A neuron-specific gene transfer by a recombinant defective Sindbis virus.
Mol. Brain Res. 63: 53-61
- SJ Won, HW
Ko, EY Kim, EC Park, NP Jung, I Choi, Oh YK, HC Shin and BJ Gwag (1999)
Nuclear Factor kappa B-mediated kainate neurotoxicity in the rat and
hamster hippocampus. Neuroscience 94(1): 83-91
- HJ Chae, JS Kang,
SB Cho, BG Jin, SJ Won, BJ Gwag and HR Kim (1999) Systemic injection
of lidocaine induced expression of c-fos mRNA and protein in adult rat
brain. Res. Commun. Mol. Pathol. Pharmacol. 104(1): 31-41
- HJ Chae, JS Kang,
SB Cho, BG Jin, SJ Won, BJ Gwag and HR Kim (1999) Systemic injection
of lidocaine induce expression of c-fos mRNA and protein in adult rat
brain. Korean J. Physiol. Pharmacol. 3: 69-74
- SJ Won, EC
Park, BR Ryu, HW Ko, S Sohn, HJ. Kwon and BJ Gwag (2000) NT-4/5 exacerbates
free radical-induced neuronal necrosis in vitro and in vivo. Neurobiol.
Dis. 7(4): 251-259
- BJ Gwag, SJ Won,
DY Kim (2002) Chapter 4. Excitotoxicity, oxidative stress, and apoptosis
in ischemic neuronal death. New concepts in cerebral ischemia (Rick
C.S. Lin Ed.), CRC press, Boca Raton, FL. pp79-112
- DY Kim, SJ Won,
BJ Gwag (2002) Analysis of mitochondrial free radical generation in
animal models of neuronal disease. Free Radic. Biol. Med. 33(5) 715-723
(Note: co-first author)
- SH Kang, YA Lee,
SJ Won, BJ Gwag (2002) Caffeine-induced neuronal death
in neonatal rat brain and cortical cell cultures. NeuroReport 13(15)
1945-1950
- SH Kim, SJ
Won, S Sohn, HJ Kwon, JY Lee, JH Park, BJ Gwag (2002) Brain-derived
neurotrophic factor can act as a pronecrotic factor through transcriptional
and translational activation of NADPH oxidase. J. Cell Biol. 159(5)
821-831
- SJ Won,
DY Kim, BJ Gwag (2002) Cellular and molecular pathways of ischemic neuronal
death. J. Biochem. Mol. Biol. 35(1): 67-86
- BR Ryu, YA Lee,
SJ Won, J-H Noh, S-Y Chang, J-M Chung, JS Choi, CK Joo, SH Yoon,
BJ Gwag (2003) The novel neuroprotective action of sulfasalazine through
blockade of NMDA receptors. J. Pharma. Exp. Thera. 305(1) 48-56
- WJ Yoon, SJ
Won, BR Ryu, BJ Gwag (2003) Blockade of ionotropic glutamate receptors
produces neuronal apoptosis through the Bax-cytochrome C-caspase pathway:
the causative role of Ca2+ deficiency. J. Neurochem. 85(2)
525-533
- SJ Won,
EY Kim, S Sohn, HJ Kwon, N-P Jung, I-H Choi, YK Oh, HC Shin, BJ Gwag
(2004) Necrosis of Neurons and Oligodendrocytes and Activation of Astrocytes
and Microglia following the Intrahippocampal Injections of Zinc. Exp.
Neurobiol. 13, 29-37
- HJ Kang, YS Choi,
S-B Hong, K-W Kim, R-S Woo, SJ Won, EJ Kim, HK Jeon, S-Y Jo,
TK Kim, R Bachoo, IJ Reynolds, BJ Gwag, H-W Lee (2004) Ectopic Expression
of the Catalytic Subunit of Telomerase Protects against Brain Injury
Resulting from Ischemia and NMDA-Induced Neurotoxicity. J. Neurosci.
24(6) 1280-1287
- SH Kim, SJ Won,
XO Mao, K Jin, DA Greenberg (2005) Involvement of protein kinase A in
cannabinoid receptor-mediated protection from oxidative neuronal injury.
J. Pharma. Exp. Thera. 313(1) 88-94
- SH Kim, SJ Won,
XO Mao, K Jin, DA Greenberg (2006) Molecular mechanisms of cannabinoid
protection from neuronal excitotoxicity. Mol. Pharmacol. 69(3) 691-696
- SJ Won,
SH Kim, XO Mao, L Xie, K Jin, DA Greenberg (2006) Reelin-deficient mice
show impaired adult neurogenesis and increased sensitivity to cerebral
ischemia. Exp. Neurol. 198(1) 250-259
- SH Kim, SJ Won,
XO Mao, C Ledent, K Jin, DA Greenberg (2006) Role for Neuronal Nitric
Oxide Synthase in Cannabinoid-induced Neurogenesis. J. Pharma. Exp.
Thera. 19(1) 150-154
- SJ
Won, L Xie, SH Kim, H Tang, Y Wang, X Mao, S Banwait, K Jin (2006)
Influence of age on the response to fibroblast growth factor-2 treatment
in a rat model of stroke. Brain Research 1123(1) 237-244
- Z Liu, Y Fan,
SJ Won, M Neumann, D Hu, L Zhou, PR Weinstein, J Liu (2006) Chronic
treatment of minocycline preserves newborn neurons and reduces functional
impairment after focal cerebral ischemia. Stroke 38(1) 146-152.
- BJ Gwag, YA Lee,
SY Ko, M Lee, DS Im, BS Yun, HR Lim, S Park, H Byun, S Son, HJ Kwon,
JE Lee, J-Y Cho, SJ Won, K-W Kim, Y Ahn, HS Moon, SH Yoon, H
Lee, J-H Noh, J-M Chung, SI Cho (2006) Marked prevention of ischemic
brain injury by Neu2000, an NMDA antagonist and antioxidant derived
from aspirin and sulfasalazine. Journal of Cerebral Blood Flow &
Metabolism 27(6) 1142-1151
- SM Hong, Z Liu,
Y Fan, M Neumann, SJ Won, D Lac, X Lum, PR Weinstein, J Liu
(2007) Reduced hippocampal neurogenesis and skill reaching performance
in adult Emx1 mutant mice. Experimental Neurology 206(1) 24-32
- H Tang, Y Wang,
L Xie, X Mao, SJ Won, V Galvan, K Jin (2007) Effect of neural
precursor proliferation level on neurogenesis in rat brain during aging
and after focal ischemia. Neurobiology of Aging Jul 16; [Epub ahead
of print]
- SW Suh, AM Hamby,
ET Gum, BS Shin, SJ Won, CT Sheline, PH Chan, RA Swanson (2008)
Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic
neuronal death. Journal of Cerebral Blood Flow & Metabolism Jun
11; [Epub ahead of print].
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Last modified: August 20 2011
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