Seok Joon Won, Ph.D.


Position: Research Scientist
Degree(s): Ph.D. (2001)
Born: Seoul, S. Korea
In Lab Since: 2007

Bio Pending


Research Interests

Pending


Selected Publications

  1. SJ Won and S Sohn (1995) Induction of metallothionein-like protein in the rat brain by intracerebroventricular cadmium treatment. Korean J Zool 38: 238-247
  2. BJ Gwag, EY Kim, BR Ryu, SJ Won, HW Ko, YJ Oh, YG Cho, SJ Ha and YC Sung (1998) A neuron-specific gene transfer by a recombinant defective Sindbis virus. Mol. Brain Res. 63: 53-61
  3. SJ Won, HW Ko, EY Kim, EC Park, NP Jung, I Choi, Oh YK, HC Shin and BJ Gwag (1999) Nuclear Factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus. Neuroscience 94(1): 83-91
  4. HJ Chae, JS Kang, SB Cho, BG Jin, SJ Won, BJ Gwag and HR Kim (1999) Systemic injection of lidocaine induced expression of c-fos mRNA and protein in adult rat brain. Res. Commun. Mol. Pathol. Pharmacol. 104(1): 31-41
  5. HJ Chae, JS Kang, SB Cho, BG Jin, SJ Won, BJ Gwag and HR Kim (1999) Systemic injection of lidocaine induce expression of c-fos mRNA and protein in adult rat brain. Korean J. Physiol. Pharmacol. 3: 69-74
  6. SJ Won, EC Park, BR Ryu, HW Ko, S Sohn, HJ. Kwon and BJ Gwag (2000) NT-4/5 exacerbates free radical-induced neuronal necrosis in vitro and in vivo. Neurobiol. Dis. 7(4): 251-259
  7. BJ Gwag, SJ Won, DY Kim (2002) Chapter 4. Excitotoxicity, oxidative stress, and apoptosis in ischemic neuronal death. New concepts in cerebral ischemia (Rick C.S. Lin Ed.), CRC press, Boca Raton, FL. pp79-112
  8. DY Kim, SJ Won, BJ Gwag (2002) Analysis of mitochondrial free radical generation in animal models of neuronal disease. Free Radic. Biol. Med. 33(5) 715-723 (Note: co-first author)
  9. SH Kang, YA Lee, SJ Won, BJ Gwag (2002) Caffeine-induced neuronal death in neonatal rat brain and cortical cell cultures. NeuroReport 13(15) 1945-1950
  10. SH Kim, SJ Won, S Sohn, HJ Kwon, JY Lee, JH Park, BJ Gwag (2002) Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase. J. Cell Biol. 159(5) 821-831
  11. SJ Won, DY Kim, BJ Gwag (2002) Cellular and molecular pathways of ischemic neuronal death. J. Biochem. Mol. Biol. 35(1): 67-86
  12. BR Ryu, YA Lee, SJ Won, J-H Noh, S-Y Chang, J-M Chung, JS Choi, CK Joo, SH Yoon, BJ Gwag (2003) The novel neuroprotective action of sulfasalazine through blockade of NMDA receptors. J. Pharma. Exp. Thera. 305(1) 48-56
  13. WJ Yoon, SJ Won, BR Ryu, BJ Gwag (2003) Blockade of ionotropic glutamate receptors produces neuronal apoptosis through the Bax-cytochrome C-caspase pathway: the causative role of Ca2+ deficiency. J. Neurochem. 85(2) 525-533
  14. SJ Won, EY Kim, S Sohn, HJ Kwon, N-P Jung, I-H Choi, YK Oh, HC Shin, BJ Gwag (2004) Necrosis of Neurons and Oligodendrocytes and Activation of Astrocytes and Microglia following the Intrahippocampal Injections of Zinc. Exp. Neurobiol. 13, 29-37
  15. HJ Kang, YS Choi, S-B Hong, K-W Kim, R-S Woo, SJ Won, EJ Kim, HK Jeon, S-Y Jo, TK Kim, R Bachoo, IJ Reynolds, BJ Gwag, H-W Lee (2004) Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity. J. Neurosci. 24(6) 1280-1287
  16. SH Kim, SJ Won, XO Mao, K Jin, DA Greenberg (2005) Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury. J. Pharma. Exp. Thera. 313(1) 88-94
  17. SH Kim, SJ Won, XO Mao, K Jin, DA Greenberg (2006) Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity. Mol. Pharmacol. 69(3) 691-696
  18. SJ Won, SH Kim, XO Mao, L Xie, K Jin, DA Greenberg (2006) Reelin-deficient mice show impaired adult neurogenesis and increased sensitivity to cerebral ischemia. Exp. Neurol. 198(1) 250-259
  19. SH Kim, SJ Won, XO Mao, C Ledent, K Jin, DA Greenberg (2006) Role for Neuronal Nitric Oxide Synthase in Cannabinoid-induced Neurogenesis. J. Pharma. Exp. Thera. 19(1) 150-154
  20. SJ Won, L Xie, SH Kim, H Tang, Y Wang, X Mao, S Banwait, K Jin (2006) Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Research 1123(1) 237-244
  21. Z Liu, Y Fan, SJ Won, M Neumann, D Hu, L Zhou, PR Weinstein, J Liu (2006) Chronic treatment of minocycline preserves newborn neurons and reduces functional impairment after focal cerebral ischemia. Stroke 38(1) 146-152.
  22. BJ Gwag, YA Lee, SY Ko, M Lee, DS Im, BS Yun, HR Lim, S Park, H Byun, S Son, HJ Kwon, JE Lee, J-Y Cho, SJ Won, K-W Kim, Y Ahn, HS Moon, SH Yoon, H Lee, J-H Noh, J-M Chung, SI Cho (2006) Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine. Journal of Cerebral Blood Flow & Metabolism 27(6) 1142-1151
  23. SM Hong, Z Liu, Y Fan, M Neumann, SJ Won, D Lac, X Lum, PR Weinstein, J Liu (2007) Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice. Experimental Neurology 206(1) 24-32
  24. H Tang, Y Wang, L Xie, X Mao, SJ Won, V Galvan, K Jin (2007) Effect of neural precursor proliferation level on neurogenesis in rat brain during aging and after focal ischemia. Neurobiology of Aging Jul 16; [Epub ahead of print]
  25. SW Suh, AM Hamby, ET Gum, BS Shin, SJ Won, CT Sheline, PH Chan, RA Swanson (2008) Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death. Journal of Cerebral Blood Flow & Metabolism Jun 11; [Epub ahead of print].
Last modified: August 20 2011